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Title: Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugsAuthor: Asuaje, Agustín / Martín, Pedro / Enrique, Nicolás Jorge / Diaz Zegarra, Leandro Agustín / Smaldini, Paola Lorena / Docena, Guillermo Horacio / Milesi, VerónicaLanguage: InglésRepository: 37Subject: Ciencias Exactas / Ciencias Médicas / antihistaminic / Apoptosis / cancer / diphenhydramine / HVCN1 / intracellular pH / leukemia / proton channels
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Title: Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathwaysAuthor: Rodenak Kladniew, Boris Emilio / Castro, María Agustina / Stärkel, Peter / De Saeger, Christine / García de Bravo, Margarita María / Crespo, RosanaLanguage: InglésRepository: 37Subject: Bioquímica / Biología / Akt/mTOR / Apoptosis / Cell cycle arrest / Hepatocellular carcinoma cells / Linalool / Ras/MAPKs / Reactive oxygen species
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Title: Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathwayLanguage: InglésRepository: 34Subject: mammalian target of rapamycin / nanoparticle / paclitaxel / phosphatidylinositol 3 kinase / protein kinase B / rapamycin / target of rapamycin kinase / animal experiment / animal model / animal tissue / antineoplastic activity / breast cancer / cancer inhibition / conference paper / controlled study / drug delivery system / drug potentiation / drug tumor level / female / in vitro study / liver / mouse / nanoencapsulation / nanopharmaceutics / nonhuman / particle size / protein phosphorylation / protein targeting / spleen / animal / apoptosis / cell proliferation / drug effects / human / Mammary Neoplasms, Animal / MCF 7 cell line / metabolism / nude mouse / signal transduction / tumor cell line / Animalia / Mus / Animals / Apoptosis / Cell Line, Tumor / Cell Proliferation / Female / Humans / MCF-7 Cells / Mice / Mice, Nude / Paclitaxel / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Signal Transduction / Sirolimus / TOR Serine-Threonine Kinases / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium OverloadLanguage: InglésRepository: 34Subject: Cell death / Microcontrollers / Calcium overload / Cell viability / Cellular injury / Intracellular Ca / Mitochondrial calcium uniporter / Mitochondrial dysfunction / Small interfering RNA / Therapeutic strategy / Calcium / calcium / small interfering RNA / calcium channel / cyclosporin / messenger RNA / mitochondrial calcium uniporter / reactive oxygen metabolite / animal cell / animal experiment / apoptosis / Article / cardiac muscle cell / cell damage / cell viability / controlled study / cytotoxicity / flow cytometry / gene targeting / hypoxia / in vitro study / mitochondrial membrane potential / mitochondrial permeability / nonhuman / oxidative stress / rat / reoxygenation / reperfusion injury / Western blotting / animal / cell hypoxia / cell line / cell survival / chemistry / cytology / drug effects / genetics / metabolism / mitochondrion / myocardial ischemia reperfusion injury / pathology / RNA interference / Cells / Nucleic Acids / Animals / Apoptosis / Calcium Channels / Cell Hypoxia / Cell Line / Cell Survival / Cyclosporine / Membrane Potential, Mitochondrial / Mitochondria / Myocardial Reperfusion Injury / Myocytes, Cardiac / Oxidative Stress / Rats / Reactive Oxygen Species / RNA Interference / RNA, Messenger / RNA, Small Interfering / 7 INGENIERÍA Y TECNOLOGÍA
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