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Title: Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathwayLanguage: InglésRepository: 34Subject: mammalian target of rapamycin / nanoparticle / paclitaxel / phosphatidylinositol 3 kinase / protein kinase B / rapamycin / target of rapamycin kinase / animal experiment / animal model / animal tissue / antineoplastic activity / breast cancer / cancer inhibition / conference paper / controlled study / drug delivery system / drug potentiation / drug tumor level / female / in vitro study / liver / mouse / nanoencapsulation / nanopharmaceutics / nonhuman / particle size / protein phosphorylation / protein targeting / spleen / animal / apoptosis / cell proliferation / drug effects / human / Mammary Neoplasms, Animal / MCF 7 cell line / metabolism / nude mouse / signal transduction / tumor cell line / Animalia / Mus / Animals / Apoptosis / Cell Line, Tumor / Cell Proliferation / Female / Humans / MCF-7 Cells / Mice / Mice, Nude / Paclitaxel / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Signal Transduction / Sirolimus / TOR Serine-Threonine Kinases / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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