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Title: Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathwayLanguage: InglésRepository: 34Subject: mammalian target of rapamycin / nanoparticle / paclitaxel / phosphatidylinositol 3 kinase / protein kinase B / rapamycin / target of rapamycin kinase / animal experiment / animal model / animal tissue / antineoplastic activity / breast cancer / cancer inhibition / conference paper / controlled study / drug delivery system / drug potentiation / drug tumor level / female / in vitro study / liver / mouse / nanoencapsulation / nanopharmaceutics / nonhuman / particle size / protein phosphorylation / protein targeting / spleen / animal / apoptosis / cell proliferation / drug effects / human / Mammary Neoplasms, Animal / MCF 7 cell line / metabolism / nude mouse / signal transduction / tumor cell line / Animalia / Mus / Animals / Apoptosis / Cell Line, Tumor / Cell Proliferation / Female / Humans / MCF-7 Cells / Mice / Mice, Nude / Paclitaxel / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Signal Transduction / Sirolimus / TOR Serine-Threonine Kinases / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Health and economic benefits of improved injury prevention and trauma care worldwideLanguage: InglésRepository: 34Subject: accident prevention / age distribution / article / cause of death / economic benefit / health care system / high income country / human / low income country / middle income country / morbidity / mortality / quality adjusted life year / social class / socioeconomics / traumatology / developing country / economics / health / Wounds and Injuries / Developing Countries / Global Health / Humans / Quality-Adjusted Life Years / 7 INGENIERÍA Y TECNOLOGÍA
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Title: The effect of anterior cruciate ligament injury on bone curvature: Exploratory analysis in the KANON trialLanguage: InglésRepository: 34Subject: adult / age / anterior cruciate ligament injury / article / body mass / bone curvature / exploratory research / female / femur / femur condyle / fracture / human / knee meniscus rupture / longitudinal study / major clinical study / male / musculoskeletal system parameters / nuclear magnetic resonance imaging / nuclear magnetic resonance scanner / osteochondral fracture / priority journal / randomized controlled trial (topic) / sex / tibia / adolescent / anterior cruciate ligament / anterior cruciate ligament reconstruction / complication / controlled study / injuries / Knee Injuries / pathology / physiotherapy / randomized controlled trial / time / treatment outcome / young adult / Adolescent / Adult / Anterior Cruciate Ligament / Anterior Cruciate Ligament Reconstruction / Body Mass Index / Female / Femur / Humans / Longitudinal Studies / Magnetic Resonance Imaging / Male / Physical Therapy Modalities / Tibia / Time Factors / Treatment Outcome / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Quantitative 3D MRI reveals limited intra-lesional bony overgrowth at1 year after microfracture-based cartilage repairLanguage: InglésRepository: 34Subject: adult / article / bone disease / cartilage / clinical feature / correlation analysis / disease classification / fracture treatment / human / image reconstruction / intralesional bony overgrowth / microfracture based cartilage repair / multicenter study (topic) / nuclear magnetic resonance imaging / priority journal / quantitative analysis / randomized controlled trial (topic) / recurrent disease / three dimensional imaging / adolescent / articular cartilage / callus / chondroplasty / clinical trial / comparative study / controlled study / evaluation study / female / follow up / Knee Injuries / male / middle aged / multicenter study / procedures / randomized controlled trial / risk assessment / time / treatment outcome / young adult / Adolescent / Adult / Arthroplasty, Subchondral / Bony Callus / Cartilage, Articular / Evaluation Studies as Topic / Female / Follow-Up Studies / Humans / Imaging, Three-Dimensional / Magnetic Resonance Imaging / Male / Middle Aged / Risk Assessment / Time Factors / Treatment Outcome / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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