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Title: The impact of LEP G-2548A and LEPR Gln223Arg polymorphisms on adiposity, leptin, and leptin-receptor serum levels in a Mexican Mestizo populationLanguage: InglésRepository: 34Subject: arginine / leptin / leptin receptor / leptin receptor, human / adult / Article / body fat / clinical article / controlled study / cross-sectional study / fat mass / female / genetic marker / genetic polymorphism / genotype / heterozygote / human / lipid metabolism / male / Mexican / obesity / population research / protein blood level / blood / body mass / genetic predisposition / genetics / Mexican American / Mexico / middle aged / pathology / single nucleotide polymorphism / Adiposity / Adult / Body Mass Index / Female / Genetic Predisposition to Disease / Genotype / Humans / Leptin / Lipid Metabolism / Male / Mexican Americans / Middle Aged / Obesity / Polymorphism, Single Nucleotide / Receptors, Leptin / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Fanconi Anemia and Laron SyndromeLanguage: InglésRepository: 34Subject: Fanconi anemia group A protein / Fanconi anemia group G protein / Fanconi anemia group I protein / Fanconi anemia group L protein / genomic DNA / growth hormone / IGFBP3 protein / PALB2 protein / protein / somatomedin binding protein 3 / somatomedin C / STAT5b protein / unclassified drug / growth hormone receptor / human growth hormone / IGF1 protein, human / IGFBP3 protein, human / adult / Article / biochemical analysis / case report / clinical feature / disease association / Fanconi anemia / female / genetic variation / heterozygote / hospital admission / human / Laron syndrome / missense mutation / molecular diagnosis / molecular pathology / next generation sequencing / physical examination / protein analysis / protein blood level / provocation test / short stature / signal transduction / tooth development / young adult / blood / body height / complication / genetics / metabolism / Mexico / pathology / Body Height / Fanconi Anemia / Female / Human Growth Hormone / Humans / Insulin-Like Growth Factor Binding Protein 3 / Insulin-Like Growth Factor I / Laron Syndrome / Receptors, Somatotropin / Signal Transduction / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma CellsLanguage: InglésRepository: 34Subject: Article / bioengineering / cancer survival / cell communication / cell function / cell interaction / DNA damage / gene dosage / gene expression / gene overexpression / gene regulatory network / genetic association / genetic variability / human / network reverse engineering / outcome assessment / polarization / prediction / prognosis / prostate cancer cell line / prostate carcinoma / prostate epithelium cell / signal transduction / transcription regulation / validation process / Bayes theorem / biological model / biology / cell line / coculture / cytology / epithelium cell / gene expression profiling / genetics / male / metabolism / pathology / prostate / prostate tumor / tumor cell line / Bayes Theorem / Cell Communication / Cell Line / Cell Line, Tumor / Coculture Techniques / Computational Biology / Epithelial Cells / Gene Expression Profiling / Gene Regulatory Networks / Humans / Male / Models, Biological / Prostate / Prostatic Neoplasms / Signal Transduction / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium OverloadLanguage: InglésRepository: 34Subject: Cell death / Microcontrollers / Calcium overload / Cell viability / Cellular injury / Intracellular Ca / Mitochondrial calcium uniporter / Mitochondrial dysfunction / Small interfering RNA / Therapeutic strategy / Calcium / calcium / small interfering RNA / calcium channel / cyclosporin / messenger RNA / mitochondrial calcium uniporter / reactive oxygen metabolite / animal cell / animal experiment / apoptosis / Article / cardiac muscle cell / cell damage / cell viability / controlled study / cytotoxicity / flow cytometry / gene targeting / hypoxia / in vitro study / mitochondrial membrane potential / mitochondrial permeability / nonhuman / oxidative stress / rat / reoxygenation / reperfusion injury / Western blotting / animal / cell hypoxia / cell line / cell survival / chemistry / cytology / drug effects / genetics / metabolism / mitochondrion / myocardial ischemia reperfusion injury / pathology / RNA interference / Cells / Nucleic Acids / Animals / Apoptosis / Calcium Channels / Cell Hypoxia / Cell Line / Cell Survival / Cyclosporine / Membrane Potential, Mitochondrial / Mitochondria / Myocardial Reperfusion Injury / Myocytes, Cardiac / Oxidative Stress / Rats / Reactive Oxygen Species / RNA Interference / RNA, Messenger / RNA, Small Interfering / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Improved Diagnostic Multimodal Biomarkers for Alzheimer's Disease and Mild Cognitive ImpairmentLanguage: InglésRepository: 34Subject: apolipoprotein D / biological marker / complement component C3 / monocyte chemotactic protein 4 / tau protein / aged / Alzheimer disease / angular gyrus / Article / calibration / case control study / cerebrospinal fluid analysis / classifier / clinical feature / controlled study / data base / data mining / diagnostic accuracy / diagnostic test accuracy study / diagnostic value / disease classification / erythrocyte count / female / genetic algorithm / hippocampus / human / lateral orbitofrontal cortex / major clinical study / male / medial orbitofrontal cortex / medical history / methodology / middle temporal gyrus / mild cognitive impairment / nuclear magnetic resonance imaging / positron emission tomography / protein blood level / sensitivity and specificity / superior frontal gyrus / temporal lobe / voxel based morphometry / cognitive defect / diagnostic imaging / early diagnosis / factual database / genetics / multimodal imaging / pathology / radiography / Alzheimer Disease / Biomarkers / Cognitive Dysfunction / Databases, Factual / Early Diagnosis / Humans / Magnetic Resonance Imaging / Multimodal Imaging / Radiography / 7 INGENIERÍA Y TECNOLOGÍA
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Title: IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architectureLanguage: InglésRepository: 34Subject: acute phase protein / autacoid / lipid / messenger RNA / scleroprotein / somatomedin C / cadherin / cytoskeleton protein / insulin-like growth factor-1, mouse / somatomedin receptor / tight junction protein / acute phase response / animal experiment / animal tissue / Article / cell junction / cell polarity / controlled study / cytoskeleton / extracellular matrix / gene expression regulation / gene overexpression / heterozygosity / histology / igf1 gene / inflammation / lipid peroxidation / liver structure / liver tissue / male / microarray analysis / mouse / murine model / nonhuman / oxidative stress / protein analysis / protein blood level / protein deficiency / protein function / reverse transcription polymerase chain reaction / wild type / animal / comparative study / cross breeding / desmosome / gene expression profiling / genetics / hepatitis / immunology / liver / metabolism / pathology / subcutaneous drug administration / transgenic mouse / Acute-Phase Proteins / Animals / Cadherins / Crosses, Genetic / Cytoskeletal Proteins / Desmosomes / Extracellular Matrix Proteins / Gene Expression Profiling / Gene Expression Regulation / Hepatitis / Inflammation Mediators / Injections, Subcutaneous / Insulin-Like Growth Factor I / Lipid Peroxidation / Liver / Male / Mice / Mice, Transgenic / Oxidative Stress / Receptors, Somatomedin / Tight Junction Proteins / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteinsLanguage: InglésRepository: 34Subject: angiotensin II / calcium / connective tissue growth factor / contractile protein / protein Grem1 / scleroprotein / somatomedin B / somatomedin B receptor / somatomedin binding protein 1 / somatomedin binding protein 2 / somatomedin binding protein 3 / somatomedin binding protein 4 / somatomedin binding protein 5 / somatomedin binding protein 6 / somatomedin C / somatomedin C receptor / unclassified drug / bradykinin / animal experiment / animal model / animal tissue / Article / calcium homeostasis / controlled study / coronary artery blood flow / Ctgf gene / extracellular matrix / gene / gene expression / Grem1 gene / heart muscle contractility / heart muscle fibrosis / heart weight / histology / Igf1 gene / Igf1r gene / Igf2 gene / Igf2r gene / Igfbp1 gene / Igfbp2 gene / Igfbp3 gene / Igfbp4 gene / Igfbp5 gene / Igfbp6 gene / male / mouse / nonhuman / protein blood level / real time polymerase chain reaction / regulatory mechanism / reperfusion injury / animal / body weight / cardiac muscle / deficiency / drug effects / gene expression regulation / genetics / heart contraction / hemodynamics / metabolism / organ size / pathology / perfusion / transgenic mouse / vasoconstriction / vasodilatation / Angiotensin II / Animals / Body Weight / Bradykinin / Extracellular Matrix / Gene Expression Regulation / Hemodynamics / Insulin-Like Growth Factor I / Mice, Transgenic / Myocardial Contraction / Myocardium / Organ Size / Perfusion / Real-Time Polymerase Chain Reaction / Vasoconstriction / Vasodilation / 7 INGENIERÍA Y TECNOLOGÍA
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