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Title: Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown FatLanguage: InglésRepository: 34Subject: eprotirome / hormone receptor stimulating agent / propranolol / sobetirome / thyroid hormone receptor / thyroid hormone receptor agonist / unclassified drug / adipocyte / animal cell / animal experiment / animal tissue / Article / brown adipose tissue / cold tolerance / controlled study / in vitro study / male / metabolic disorder / mouse / nonhuman / obesity / pharmacological procedures / priority journal / receptor blocking / subcutaneous fat / thermogenesis / white adipose tissue / animal / brown adipocyte / C57BL mouse / energy metabolism / metabolism / physiology / white adipocyte / Adipocytes, Brown / Adipocytes, White / Adipose Tissue, Brown / Adipose Tissue, White / Animals / Energy Metabolism / Mice / Mice, Inbred C57BL / Obesity / Receptors, Thyroid Hormone / Thermogenesis / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Topical anti-inflammatory effects of isorhamnetin glycosides isolated from opuntia ficus-indicaLanguage: InglésRepository: 34Subject: antiinflammatory agent / cyclooxygenase 2 / flavonoid glycoside / indometacin / interleukin 6 / isorhamnetin / isorhamnetin glucosyl pentoside / isorhamnetin glucosyl rhamnoside / isorhamnetin glucosyl rhamnosyl pentoside / isorhamnetin glucosyl rhamnosyl rhamnoside / isorhamnetin glycoside derivative / nitric oxide / Opuntia ficus indica extract / plant extract / tumor necrosis factor alpha / unclassified drug / 3-methylquercetin / cytokine / glycoside / quercetin / animal cell / animal experiment / animal model / antiinflammatory activity / Article / cell proliferation / cell viability / controlled study / cytokine production / drug identification / ear edema / enzyme activity / in vitro study / in vivo study / macrophage / male / medicinal plant / mouse / nonhuman / Opuntia ficus-indica / rat / analogs and derivatives / animal / chemistry / dose response / immunology / Opuntia / Otitis Externa / treatment outcome / Wistar rat / Animals / Anti-Inflammatory Agents / Cytokines / Dose-Response Relationship, Drug / Glycosides / Male / Plant Extracts / Quercetin / Rats / Rats, Wistar / Treatment Outcome / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Supercritical CO2 foaming of thermoplastic materials derived from maize: Proof-of- concept use in mammalian cell culture applicationsLanguage: InglésRepository: 34Subject: carbon dioxide / formamide / glycerol / macrogol / plastic / plasticizer / sorbitol / starch / thermoplastic / unclassified drug / urea / vegetable protein / zein / biomaterial / 22RV1 cell line / 3T3 cell line / animal cell / Article / assay / cell adhesion / cell culture / cell proliferation / DU145 cell line / fibroblast / flour / foam / foaming / maize / mammal cell / mouse / nonhuman / plant seed / porosity / prostate cancer cell line / supercritical carbon dioxide foaming / animal / cell culture technique / cell line / human / materials testing / temperature / Mammalia / Zea mays / Animals / Biocompatible Materials / Carbon Dioxide / Cell Culture Techniques / Cell Line / Humans / Materials Testing / Mice / Porosity / Temperature / Zein / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A computational toxicogenomics approach identifies a list of highly hepatotoxic compounds from a large microarray databaseLanguage: InglésRepository: 34Subject: 1 naphthyl isothiocyanate / acetylsalicylic acid / allopurinol / allyl alcohol / amiodarone / azathioprine / benzbromarone / bromobenzene / carbamazepine / carbon tetrachloride / chlorpromazine / cimetidine / clofibrate / coumarin / cyclophosphamide / cytochrome P450 family 1 / diazepam / diclofenac / doxepin / ethionine / fluphenazine / flutamide / gemfibrozil / glibenclamide / griseofulvin / haloperidol / hexachlorobenzene / indometacin / paracetamol / unindexed drug / cytotoxin / algorithm / Article / cluster analysis / data base / gene expression / genomics / human / liver cell / liver toxicity / machine learning / microarray analysis / nonhuman / skin absorption / toxic hepatitis / xenobiotic metabolism / animal / DNA microarray / dose response / drug effects / genetic database / genetics / liver / metabolism / mouse / preclinical study / procedures / time factor / toxicogenetics / unsupervised machine learning / Animals / Chemical and Drug Induced Liver Injury / Cytotoxins / Databases, Genetic / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Genomics / Humans / Liver / Mice / Oligonucleotide Array Sequence Analysis / Time Factors / Toxicogenetics / Unsupervised Machine Learning / 7 INGENIERÍA Y TECNOLOGÍA
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Title: IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architectureLanguage: InglésRepository: 34Subject: acute phase protein / autacoid / lipid / messenger RNA / scleroprotein / somatomedin C / cadherin / cytoskeleton protein / insulin-like growth factor-1, mouse / somatomedin receptor / tight junction protein / acute phase response / animal experiment / animal tissue / Article / cell junction / cell polarity / controlled study / cytoskeleton / extracellular matrix / gene expression regulation / gene overexpression / heterozygosity / histology / igf1 gene / inflammation / lipid peroxidation / liver structure / liver tissue / male / microarray analysis / mouse / murine model / nonhuman / oxidative stress / protein analysis / protein blood level / protein deficiency / protein function / reverse transcription polymerase chain reaction / wild type / animal / comparative study / cross breeding / desmosome / gene expression profiling / genetics / hepatitis / immunology / liver / metabolism / pathology / subcutaneous drug administration / transgenic mouse / Acute-Phase Proteins / Animals / Cadherins / Crosses, Genetic / Cytoskeletal Proteins / Desmosomes / Extracellular Matrix Proteins / Gene Expression Profiling / Gene Expression Regulation / Hepatitis / Inflammation Mediators / Injections, Subcutaneous / Insulin-Like Growth Factor I / Lipid Peroxidation / Liver / Male / Mice / Mice, Transgenic / Oxidative Stress / Receptors, Somatomedin / Tight Junction Proteins / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteinsLanguage: InglésRepository: 34Subject: angiotensin II / calcium / connective tissue growth factor / contractile protein / protein Grem1 / scleroprotein / somatomedin B / somatomedin B receptor / somatomedin binding protein 1 / somatomedin binding protein 2 / somatomedin binding protein 3 / somatomedin binding protein 4 / somatomedin binding protein 5 / somatomedin binding protein 6 / somatomedin C / somatomedin C receptor / unclassified drug / bradykinin / animal experiment / animal model / animal tissue / Article / calcium homeostasis / controlled study / coronary artery blood flow / Ctgf gene / extracellular matrix / gene / gene expression / Grem1 gene / heart muscle contractility / heart muscle fibrosis / heart weight / histology / Igf1 gene / Igf1r gene / Igf2 gene / Igf2r gene / Igfbp1 gene / Igfbp2 gene / Igfbp3 gene / Igfbp4 gene / Igfbp5 gene / Igfbp6 gene / male / mouse / nonhuman / protein blood level / real time polymerase chain reaction / regulatory mechanism / reperfusion injury / animal / body weight / cardiac muscle / deficiency / drug effects / gene expression regulation / genetics / heart contraction / hemodynamics / metabolism / organ size / pathology / perfusion / transgenic mouse / vasoconstriction / vasodilatation / Angiotensin II / Animals / Body Weight / Bradykinin / Extracellular Matrix / Gene Expression Regulation / Hemodynamics / Insulin-Like Growth Factor I / Mice, Transgenic / Myocardial Contraction / Myocardium / Organ Size / Perfusion / Real-Time Polymerase Chain Reaction / Vasoconstriction / Vasodilation / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Cell source determines the immunological impact of biomimetic nanoparticlesLanguage: InglésRepository: 34Subject: Antigen-antibody reactions / Biocompatibility / Biomimetics / Cell membranes / Drug delivery / Drug products / Immunology / Nanoparticles / Biomimetic nanoparticles / Biomimicry / Comprehensive evaluation / Immunobiology / Immunological effects / Nanovector / Systemic administration / Time-lapse microscopy / Biological materials / alanine aminotransferase / aspartate aminotransferase / biomimetic material / creatinine / gamma interferon / interleukin 10 / interleukin 12 / interleukin 1alpha / interleukin 1beta / interleukin 2 / interleukin 3 / interleukin 6 / leukolike vector / multistage nanovector / nanocarrier / nanoparticle / reactive oxygen metabolite / transcription factor RelA / tumor necrosis factor alpha / unclassified drug / biomaterial / nanocapsule / animal cell / animal experiment / animal tissue / Article / biocompatibility / cell interaction / controlled study / cytokine release / drug delivery system / human / human cell / in vitro study / in vivo study / internalization / leukocyte membrane / liver function / macrophage / mononuclear phagocyte / mouse / nonhuman / opsonization / phagocytosis / priority journal / protein expression / static electricity / surface charge / time lapse imaging / zeta potential / animal / Bagg albino mouse / cell culture / comparative study / drug effects / evaluation study / immunology / innate immunity / leukocyte / Animals / Biocompatible Materials / Biomimetic Materials / Cells, Cultured / Immunity, Innate / Leukocytes / Mice / Mice, Inbred BALB C / Nanocapsules / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Genome-wide binding patterns of thyroid hormone receptor betaLanguage: InglésRepository: 34Subject: thyroid hormone receptor beta / transcription factor AP 1 / transcription factor CTCF / ligand / protein binding / RNA / 3' untranslated region / 5' untranslated region / animal experiment / animal tissue / article / binding kinetics / binding site / controlled study / gene cluster / gene control / gene expression / gene repression / gene sequence / gene targeting / genetic association / genetic transcription / genetic transfection / human / human cell / liver cell / mouse / nonhuman / nucleotide sequence / protein analysis / protein function / protein localization / sequence analysis / animal / C57BL mouse / cell line / chemistry / DNA microarray / DNA responsive element / DNA sequence / gene expression regulation / genome / HepG2 cell line / liver / metabolism / multigene family / plasmid / Animals / Binding Sites / Cell Line / Gene Expression Regulation / Genome / Hep G2 Cells / Humans / Ligands / Liver / Mice / Mice, Inbred C57BL / Multigene Family / Oligonucleotide Array Sequence Analysis / Plasmids / Protein Binding / Response Elements / Sequence Analysis, DNA / Thyroid Hormone Receptors beta / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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Title: The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob miceLanguage: InglésRepository: 34Subject: eprotirome / hormone receptor stimulating agent / liothyronine / sobetirome / thyroid hormone receptor / thyroid hormone receptor agonist / triacylglycerol / unclassified drug / 3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid / acetic acid derivative / anilide / glucose 6 phosphatase / glucose blood level / phenol derivative / animal experiment / animal model / animal tissue / Article / body temperature / controlled study / glucose tolerance / glycemic control / insulin resistance / insulin sensitivity / liver level / male / mouse / nonalcoholic fatty liver / nonhuman / ob/ob mouse / agonists / animal / biosynthesis / dose response / drug effects / enzyme induction / metabolism / mouse mutant / Non-alcoholic Fatty Liver Disease / time factor / Mus / Acetates / Anilides / Animals / Blood Glucose / Body Temperature / Dose-Response Relationship, Drug / Enzyme Induction / Glucose-6-Phosphatase / Insulin Resistance / Male / Mice / Mice, Obese / Phenols / Receptors, Thyroid Hormone / Time Factors / 7 INGENIERÍA Y TECNOLOGÍA
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