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Title: Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium OverloadLanguage: InglésRepository: 34Subject: Cell death / Microcontrollers / Calcium overload / Cell viability / Cellular injury / Intracellular Ca / Mitochondrial calcium uniporter / Mitochondrial dysfunction / Small interfering RNA / Therapeutic strategy / Calcium / calcium / small interfering RNA / calcium channel / cyclosporin / messenger RNA / mitochondrial calcium uniporter / reactive oxygen metabolite / animal cell / animal experiment / apoptosis / Article / cardiac muscle cell / cell damage / cell viability / controlled study / cytotoxicity / flow cytometry / gene targeting / hypoxia / in vitro study / mitochondrial membrane potential / mitochondrial permeability / nonhuman / oxidative stress / rat / reoxygenation / reperfusion injury / Western blotting / animal / cell hypoxia / cell line / cell survival / chemistry / cytology / drug effects / genetics / metabolism / mitochondrion / myocardial ischemia reperfusion injury / pathology / RNA interference / Cells / Nucleic Acids / Animals / Apoptosis / Calcium Channels / Cell Hypoxia / Cell Line / Cell Survival / Cyclosporine / Membrane Potential, Mitochondrial / Mitochondria / Myocardial Reperfusion Injury / Myocytes, Cardiac / Oxidative Stress / Rats / Reactive Oxygen Species / RNA Interference / RNA, Messenger / RNA, Small Interfering / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteinsLanguage: InglésRepository: 34Subject: angiotensin II / calcium / connective tissue growth factor / contractile protein / protein Grem1 / scleroprotein / somatomedin B / somatomedin B receptor / somatomedin binding protein 1 / somatomedin binding protein 2 / somatomedin binding protein 3 / somatomedin binding protein 4 / somatomedin binding protein 5 / somatomedin binding protein 6 / somatomedin C / somatomedin C receptor / unclassified drug / bradykinin / animal experiment / animal model / animal tissue / Article / calcium homeostasis / controlled study / coronary artery blood flow / Ctgf gene / extracellular matrix / gene / gene expression / Grem1 gene / heart muscle contractility / heart muscle fibrosis / heart weight / histology / Igf1 gene / Igf1r gene / Igf2 gene / Igf2r gene / Igfbp1 gene / Igfbp2 gene / Igfbp3 gene / Igfbp4 gene / Igfbp5 gene / Igfbp6 gene / male / mouse / nonhuman / protein blood level / real time polymerase chain reaction / regulatory mechanism / reperfusion injury / animal / body weight / cardiac muscle / deficiency / drug effects / gene expression regulation / genetics / heart contraction / hemodynamics / metabolism / organ size / pathology / perfusion / transgenic mouse / vasoconstriction / vasodilatation / Angiotensin II / Animals / Body Weight / Bradykinin / Extracellular Matrix / Gene Expression Regulation / Hemodynamics / Insulin-Like Growth Factor I / Mice, Transgenic / Myocardial Contraction / Myocardium / Organ Size / Perfusion / Real-Time Polymerase Chain Reaction / Vasoconstriction / Vasodilation / 7 INGENIERÍA Y TECNOLOGÍA
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