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Title: Towards better BBB passage prediction using an extensive and curated data setAuthor: Brito-Sánchez Y. / Marrero-Ponce Y. / Barigye S.J. / Yaber-Goenaga I. / Morell Pérez C. / Le-Thi-Thu H. / Cherkasov A.Language: InglésRepository: 61Subject: BBB endpoint / Blood£brain barrier / Dragon descriptor / Linear discriminant analysis / Multiple linear regression / P-glycoprotein / Quantitative structure pharmacokinetic (property) relationship / Central nervous system agents / Multidrug resistance protein / Octanol / Water / Article / Blood-Brain Barrier / Brain disease / Central nervous system / Chemical structure / Cluster analysis / Computer program / Data analysis / Discriminant analysis / Drug penetration / Drug research / Drug targeting / Drug transport / Genetic algorithm / High throughput screening / Human / Machine learning / Molecular weight / Molecule / Multiple linear regression analysis / Partition coefficient / Prediction / Priority journal / Quantitative structure activity relation / Quantitative structure pharmacokinetic relation / Statistical analysis / Statistical model / Statistical parameters / Animal / Biological model / Computer simulation / Physiology / Animals / Humans / Models, Cardiovascular / Models, Neurological
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Title: The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob miceLanguage: InglésRepository: 34Subject: eprotirome / hormone receptor stimulating agent / liothyronine / sobetirome / thyroid hormone receptor / thyroid hormone receptor agonist / triacylglycerol / unclassified drug / 3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid / acetic acid derivative / anilide / glucose 6 phosphatase / glucose blood level / phenol derivative / animal experiment / animal model / animal tissue / Article / body temperature / controlled study / glucose tolerance / glycemic control / insulin resistance / insulin sensitivity / liver level / male / mouse / nonalcoholic fatty liver / nonhuman / ob/ob mouse / agonists / animal / biosynthesis / dose response / drug effects / enzyme induction / metabolism / mouse mutant / Non-alcoholic Fatty Liver Disease / time factor / Mus / Acetates / Anilides / Animals / Blood Glucose / Body Temperature / Dose-Response Relationship, Drug / Enzyme Induction / Glucose-6-Phosphatase / Insulin Resistance / Male / Mice / Mice, Obese / Phenols / Receptors, Thyroid Hormone / Time Factors / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Changes in T-tubules and sarcoplasmic reticulum in ventricular myocytes in early cardiac hypertrophy in a pressure overload rat modelLanguage: InglésRepository: 34Subject: calcium ion / aniline derivative / calcium / Fluo 4 / fluorescent dye / ion / xanthene derivative / animal cell / animal experiment / animal model / animal tissue / aorta constriction / Article / beta adrenergic stimulation / bone mass / calcium signaling / cell count / cell structure / cell volume / controlled study / decay time constant / density / diffusion / ex vivo study / heart left ventricle overload / heart muscle cell / heart muscle contractility / heart performance / heart ventricle hypertrophy / heart weight / male / nonhuman / priority journal / rat / sarcolemma / sarcoplasmic reticulum / tissue distribution / transverse tubular system / animal / cardiac muscle cell / cardiomegaly / cell culture / chemistry / confocal microscopy / cytology / disease model / fluorescence recovery after photobleaching / metabolism / microtubule / pathology / pressure / Wistar rat / Aniline Compounds / Animals / Calcium / Calcium Signaling / Cardiomegaly / Cells, Cultured / Disease Models, Animal / Fluorescence Recovery After Photobleaching / Fluorescent Dyes / Ions / Male / Microscopy, Confocal / Microtubules / Myocytes, Cardiac / Pressure / Rats / Rats, Wistar / Sarcoplasmic Reticulum / Xanthenes / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown FatLanguage: InglésRepository: 34Subject: eprotirome / hormone receptor stimulating agent / propranolol / sobetirome / thyroid hormone receptor / thyroid hormone receptor agonist / unclassified drug / adipocyte / animal cell / animal experiment / animal tissue / Article / brown adipose tissue / cold tolerance / controlled study / in vitro study / male / metabolic disorder / mouse / nonhuman / obesity / pharmacological procedures / priority journal / receptor blocking / subcutaneous fat / thermogenesis / white adipose tissue / animal / brown adipocyte / C57BL mouse / energy metabolism / metabolism / physiology / white adipocyte / Adipocytes, Brown / Adipocytes, White / Adipose Tissue, Brown / Adipose Tissue, White / Animals / Energy Metabolism / Mice / Mice, Inbred C57BL / Obesity / Receptors, Thyroid Hormone / Thermogenesis / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Topical anti-inflammatory effects of isorhamnetin glycosides isolated from opuntia ficus-indicaLanguage: InglésRepository: 34Subject: antiinflammatory agent / cyclooxygenase 2 / flavonoid glycoside / indometacin / interleukin 6 / isorhamnetin / isorhamnetin glucosyl pentoside / isorhamnetin glucosyl rhamnoside / isorhamnetin glucosyl rhamnosyl pentoside / isorhamnetin glucosyl rhamnosyl rhamnoside / isorhamnetin glycoside derivative / nitric oxide / Opuntia ficus indica extract / plant extract / tumor necrosis factor alpha / unclassified drug / 3-methylquercetin / cytokine / glycoside / quercetin / animal cell / animal experiment / animal model / antiinflammatory activity / Article / cell proliferation / cell viability / controlled study / cytokine production / drug identification / ear edema / enzyme activity / in vitro study / in vivo study / macrophage / male / medicinal plant / mouse / nonhuman / Opuntia ficus-indica / rat / analogs and derivatives / animal / chemistry / dose response / immunology / Opuntia / Otitis Externa / treatment outcome / Wistar rat / Animals / Anti-Inflammatory Agents / Cytokines / Dose-Response Relationship, Drug / Glycosides / Male / Plant Extracts / Quercetin / Rats / Rats, Wistar / Treatment Outcome / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Supercritical CO2 foaming of thermoplastic materials derived from maize: Proof-of- concept use in mammalian cell culture applicationsLanguage: InglésRepository: 34Subject: carbon dioxide / formamide / glycerol / macrogol / plastic / plasticizer / sorbitol / starch / thermoplastic / unclassified drug / urea / vegetable protein / zein / biomaterial / 22RV1 cell line / 3T3 cell line / animal cell / Article / assay / cell adhesion / cell culture / cell proliferation / DU145 cell line / fibroblast / flour / foam / foaming / maize / mammal cell / mouse / nonhuman / plant seed / porosity / prostate cancer cell line / supercritical carbon dioxide foaming / animal / cell culture technique / cell line / human / materials testing / temperature / Mammalia / Zea mays / Animals / Biocompatible Materials / Carbon Dioxide / Cell Culture Techniques / Cell Line / Humans / Materials Testing / Mice / Porosity / Temperature / Zein / 7 INGENIERÍA Y TECNOLOGÍA
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