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Title: A computational toxicogenomics approach identifies a list of highly hepatotoxic compounds from a large microarray databaseLanguage: InglésRepository: 34Subject: 1 naphthyl isothiocyanate / acetylsalicylic acid / allopurinol / allyl alcohol / amiodarone / azathioprine / benzbromarone / bromobenzene / carbamazepine / carbon tetrachloride / chlorpromazine / cimetidine / clofibrate / coumarin / cyclophosphamide / cytochrome P450 family 1 / diazepam / diclofenac / doxepin / ethionine / fluphenazine / flutamide / gemfibrozil / glibenclamide / griseofulvin / haloperidol / hexachlorobenzene / indometacin / paracetamol / unindexed drug / cytotoxin / algorithm / Article / cluster analysis / data base / gene expression / genomics / human / liver cell / liver toxicity / machine learning / microarray analysis / nonhuman / skin absorption / toxic hepatitis / xenobiotic metabolism / animal / DNA microarray / dose response / drug effects / genetic database / genetics / liver / metabolism / mouse / preclinical study / procedures / time factor / toxicogenetics / unsupervised machine learning / Animals / Chemical and Drug Induced Liver Injury / Cytotoxins / Databases, Genetic / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Genomics / Humans / Liver / Mice / Oligonucleotide Array Sequence Analysis / Time Factors / Toxicogenetics / Unsupervised Machine Learning / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Human adipose derived stem cells regress fibrosis in a chronic renal fibrotic model induced by adenineLanguage: InglésRepository: 34Subject: ACTA2 protein / adenine / alpha smooth muscle actin / COL1A1 protein / collagen / connective tissue growth factor / creatinine / messenger RNA / transforming growth factor beta1 / unclassified drug / urea / adipose derived stem cell / animal experiment / animal model / animal tissue / Article / controlled study / creatinine blood level / creatinine urine level / human / human cell / kidney fibrosis / male / nonhuman / rat / stem cell transplantation / treatment outcome / urea blood level / adipose tissue / animal / cell culture / chemically induced / cytology / fibrosis / gene expression profiling / genetics / kidney disease / stem cell / Wistar rat / Adenine / Adipose Tissue / Animals / Cells, Cultured / Fibrosis / Gene Expression Profiling / Humans / Kidney Diseases / Male / Rats / Rats, Wistar / Stem Cells / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Shorter men live longer: Association of height with longevity and FOXO3 genotype in American men of Japanese ancestryLanguage: InglésRepository: 34Subject: insulin / somatomedin C / transcription factor FKHRL1 / forkhead transcription factor / FOXO3 protein, human / adult / age / age of death / aged / article / Asian American / body height / cancer mortality / cohort analysis / controlled study / follow up / FOXO3 gene / genetic analysis / genetic association / genetic variability / genotype / human / insulin blood level / life expectancy / longevity / male / observational study / population research / prospective study / regulator gene / risk factor / signal transduction / single nucleotide polymorphism / smoking / blood / diet restriction / genetics / middle aged / physiology / proportional hazards model / statistics and numerical data / Aged / Asian Americans / Body Height / Fasting / Forkhead Transcription Factors / Genotype / Humans / Insulin / Longevity / Male / Middle Aged / Polymorphism, Single Nucleotide / Proportional Hazards Models / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Enrichment of the cancer stem phenotype in sphere cultures of prostate cancer cell lines occurs through activation of developmental pathways mediated by the transcriptional regulator ΔNp63αLanguage: InglésRepository: 34Subject: Bcl2 related protein A1 / CD133 antigen / delta NP63alpha protein / early growth response factor 1 / regulator protein / unclassified drug / glycoprotein / leukocyte antigen / peptide / PROM1 protein, human / tumor marker / Article / BCL2A1 gene / bioassay / cancer stem cell / CD133+ cancer stem cell / cell growth / clonogenesis / controlled study / drug resistance / EGR1 gene / flow cytometry / GAS1 gene / gene expression profiling / human / human cell / IGFBP3 gene / in vitro study / in vivo study / male / phenotype / prostasphere assay / prostate cancer cell line / protein expression / protein function / transcription regulation / tumor invasion / upregulation / gene expression regulation / metabolism / pathology / prostate tumor / tumor cell line / AC133 Antigen / Antigens, CD / Biomarkers, Tumor / Cell Line, Tumor / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Glycoproteins / Humans / Male / Neoplastic Stem Cells / Peptides / Phenotype / Prostatic Neoplasms / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Automated Classification of Severity in Cardiac Dyssynchrony Merging Clinical Data and Mechanical DescriptorsLanguage: InglésRepository: 34Subject: behavior / cardiac resynchronization therapy / classification / classifier / clinical article / control group / controlled study / factor analysis / female / follow up / heart left ventricle ejection fraction / heart ventricle contraction / human / male / radionuclide ventriculography / volunteer / adult / algorithm / angiography / calibration / diagnostic imaging / heart / heart arrhythmia / heart contraction / heart failure / heart left ventricle function / heart muscle conduction system / heart ventricle / information processing / medical informatics / normal human / pathophysiology / procedures / reproducibility / signal processing / treatment outcome / Adult / Algorithms / Angiography / Arrhythmias, Cardiac / Automatic Data Processing / Calibration / Cardiac Resynchronization Therapy / Female / Healthy Volunteers / Heart / Heart Conduction System / Heart Failure / Heart Ventricles / Humans / Male / Medical Informatics / Myocardial Contraction / Reproducibility of Results / Signal Processing, Computer-Assisted / Treatment Outcome / Ventricular Dysfunction, Left / Ventricular Function, Left / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Bilateral Image Subtraction and Multivariate Models for the Automated Triaging of Screening MammogramsLanguage: InglésRepository: 34Subject: Article / automation / breast cancer / cancer risk / cancer screening / computer assisted diagnosis / controlled study / data base / diagnostic accuracy / diagnostic test accuracy study / digital imaging / human / image enhancement / image subtraction / major clinical study / mammography / methodology / probability / radiologist / sensitivity and specificity / tumor calcinosis / validation process / workflow / automated pattern recognition / breast tumor / computer simulation / diagnostic imaging / early cancer diagnosis / echography / emergency health service / female / middle aged / multivariate analysis / procedures / reproducibility / statistical model / Breast Neoplasms / Computer Simulation / Early Detection of Cancer / Female / Humans / Image Interpretation, Computer-Assisted / Mammography / Middle Aged / Models, Statistical / Multivariate Analysis / Pattern Recognition, Automated / Reproducibility of Results / Sensitivity and Specificity / Subtraction Technique / Triage / Ultrasonography
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Title: Influence of PEEK Coating on Hip Implant Stress Shielding: A Finite Element AnalysisLanguage: InglésRepository: 34Subject: polyetheretherketone / titanium / alloy / biocompatible coated material / hydroxyapatite / ketone / macrogol derivative / Article / body weight / bone regeneration / cortical bone / electrophoresis / finite element analysis / hip prosthesis / mechanical stress / osteolysis / stress shielding / surface property / tooth implant / trabecular bone / chemistry / devices / femur / hip replacement / human / osseointegration / pathology / pressure / procedures / prosthesis design / theoretical model / Alloys / Arthroplasty, Replacement, Hip / Coated Materials, Biocompatible / Durapatite / Femur / Finite Element Analysis / Hip Prosthesis / Humans / Ketones / Models, Theoretical / Osseointegration / Polyethylene Glycols / Pressure / Prosthesis Design / Stress, Mechanical / Titanium / 7 INGENIERÍA Y TECNOLOGÍA
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Title: The effect of anterior cruciate ligament injury on bone curvature: Exploratory analysis in the KANON trialLanguage: InglésRepository: 34Subject: adult / age / anterior cruciate ligament injury / article / body mass / bone curvature / exploratory research / female / femur / femur condyle / fracture / human / knee meniscus rupture / longitudinal study / major clinical study / male / musculoskeletal system parameters / nuclear magnetic resonance imaging / nuclear magnetic resonance scanner / osteochondral fracture / priority journal / randomized controlled trial (topic) / sex / tibia / adolescent / anterior cruciate ligament / anterior cruciate ligament reconstruction / complication / controlled study / injuries / Knee Injuries / pathology / physiotherapy / randomized controlled trial / time / treatment outcome / young adult / Adolescent / Adult / Anterior Cruciate Ligament / Anterior Cruciate Ligament Reconstruction / Body Mass Index / Female / Femur / Humans / Longitudinal Studies / Magnetic Resonance Imaging / Male / Physical Therapy Modalities / Tibia / Time Factors / Treatment Outcome / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Relationship between irisin concentration and serum cytokines in mother and newbornLanguage: InglésRepository: 34Subject: cytokine / fatty acid / gamma interferon inducible protein 10 / interleukin 1 receptor blocking agent / interleukin 1beta / interleukin 5 / interleukin 7 / irisin / plasma protein / antioxidant / biological marker / CXCL10 protein, human / fibronectin / FNDC5 protein, human / interleukin derivative / adolescent / adult / arterial blood / Article / blood sampling / body weight / cesarean section / chemical parameters / clinical article / controlled study / cytokine blood level / female / gamma interferon inducible protein 10 blood level / hormone blood level / hormone determination / human / interleukin 1beta blood level / interleukin 5 blood level / interleukin 7 blood level / irisin blood level / labor / male / maternal blood / newborn / obesity / perinatal period / prediction / pregnancy diabetes mellitus / progeny / protein blood level / protein determination / total antioxidant capacity / umbilical cord blood / venous blood / blood / body mass / fetus blood / metabolism / mother / multivariate analysis / pregnancy / statistical model / young adult / Adolescent / Adult / Antioxidants / Biomarkers / Body Mass Index / Chemokine CXCL10 / Cytokines / Diabetes, Gestational / Fatty Acids / Female / Fetal Blood / Fibronectins / Humans / Infant, Newborn / Interleukins / Linear Models / Mothers / Multivariate Analysis / Pregnancy / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and ObesityLanguage: InglésRepository: 34Subject: albumin / glucose / irisin / low density lipoprotein cholesterol / triacylglycerol / fibronectin / FNDC5 protein, human / aerobic exercise / age / albumin blood level / anaerobic exercise / anthropometric parameters / Article / body composition / body mass / child / childhood obesity / cholesterol blood level / clinical article / controlled study / disease association / fat free mass / fat mass / female / glucose blood level / hormone blood level / human / male / metabolic parameters / muscle mass / physical activity / sex difference / underweight / waist circumference / blood / exercise / pathology / pathophysiology / preschool child / Body Mass Index / Child / Child, Preschool / Exercise / Female / Fibronectins / Humans / Male / Pediatric Obesity / Thinness / 7 INGENIERÍA Y TECNOLOGÍA
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