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Title: A computational toxicogenomics approach identifies a list of highly hepatotoxic compounds from a large microarray databaseLanguage: InglésRepository: 34Subject: 1 naphthyl isothiocyanate / acetylsalicylic acid / allopurinol / allyl alcohol / amiodarone / azathioprine / benzbromarone / bromobenzene / carbamazepine / carbon tetrachloride / chlorpromazine / cimetidine / clofibrate / coumarin / cyclophosphamide / cytochrome P450 family 1 / diazepam / diclofenac / doxepin / ethionine / fluphenazine / flutamide / gemfibrozil / glibenclamide / griseofulvin / haloperidol / hexachlorobenzene / indometacin / paracetamol / unindexed drug / cytotoxin / algorithm / Article / cluster analysis / data base / gene expression / genomics / human / liver cell / liver toxicity / machine learning / microarray analysis / nonhuman / skin absorption / toxic hepatitis / xenobiotic metabolism / animal / DNA microarray / dose response / drug effects / genetic database / genetics / liver / metabolism / mouse / preclinical study / procedures / time factor / toxicogenetics / unsupervised machine learning / Animals / Chemical and Drug Induced Liver Injury / Cytotoxins / Databases, Genetic / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Genomics / Humans / Liver / Mice / Oligonucleotide Array Sequence Analysis / Time Factors / Toxicogenetics / Unsupervised Machine Learning / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Enrichment of the cancer stem phenotype in sphere cultures of prostate cancer cell lines occurs through activation of developmental pathways mediated by the transcriptional regulator ΔNp63αLanguage: InglésRepository: 34Subject: Bcl2 related protein A1 / CD133 antigen / delta NP63alpha protein / early growth response factor 1 / regulator protein / unclassified drug / glycoprotein / leukocyte antigen / peptide / PROM1 protein, human / tumor marker / Article / BCL2A1 gene / bioassay / cancer stem cell / CD133+ cancer stem cell / cell growth / clonogenesis / controlled study / drug resistance / EGR1 gene / flow cytometry / GAS1 gene / gene expression profiling / human / human cell / IGFBP3 gene / in vitro study / in vivo study / male / phenotype / prostasphere assay / prostate cancer cell line / protein expression / protein function / transcription regulation / tumor invasion / upregulation / gene expression regulation / metabolism / pathology / prostate tumor / tumor cell line / AC133 Antigen / Antigens, CD / Biomarkers, Tumor / Cell Line, Tumor / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Glycoproteins / Humans / Male / Neoplastic Stem Cells / Peptides / Phenotype / Prostatic Neoplasms / 7 INGENIERÍA Y TECNOLOGÍA
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Title: IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architectureLanguage: InglésRepository: 34Subject: acute phase protein / autacoid / lipid / messenger RNA / scleroprotein / somatomedin C / cadherin / cytoskeleton protein / insulin-like growth factor-1, mouse / somatomedin receptor / tight junction protein / acute phase response / animal experiment / animal tissue / Article / cell junction / cell polarity / controlled study / cytoskeleton / extracellular matrix / gene expression regulation / gene overexpression / heterozygosity / histology / igf1 gene / inflammation / lipid peroxidation / liver structure / liver tissue / male / microarray analysis / mouse / murine model / nonhuman / oxidative stress / protein analysis / protein blood level / protein deficiency / protein function / reverse transcription polymerase chain reaction / wild type / animal / comparative study / cross breeding / desmosome / gene expression profiling / genetics / hepatitis / immunology / liver / metabolism / pathology / subcutaneous drug administration / transgenic mouse / Acute-Phase Proteins / Animals / Cadherins / Crosses, Genetic / Cytoskeletal Proteins / Desmosomes / Extracellular Matrix Proteins / Gene Expression Profiling / Gene Expression Regulation / Hepatitis / Inflammation Mediators / Injections, Subcutaneous / Insulin-Like Growth Factor I / Lipid Peroxidation / Liver / Male / Mice / Mice, Transgenic / Oxidative Stress / Receptors, Somatomedin / Tight Junction Proteins / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Relationship between irisin concentration and serum cytokines in mother and newbornLanguage: InglésRepository: 34Subject: cytokine / fatty acid / gamma interferon inducible protein 10 / interleukin 1 receptor blocking agent / interleukin 1beta / interleukin 5 / interleukin 7 / irisin / plasma protein / antioxidant / biological marker / CXCL10 protein, human / fibronectin / FNDC5 protein, human / interleukin derivative / adolescent / adult / arterial blood / Article / blood sampling / body weight / cesarean section / chemical parameters / clinical article / controlled study / cytokine blood level / female / gamma interferon inducible protein 10 blood level / hormone blood level / hormone determination / human / interleukin 1beta blood level / interleukin 5 blood level / interleukin 7 blood level / irisin blood level / labor / male / maternal blood / newborn / obesity / perinatal period / prediction / pregnancy diabetes mellitus / progeny / protein blood level / protein determination / total antioxidant capacity / umbilical cord blood / venous blood / blood / body mass / fetus blood / metabolism / mother / multivariate analysis / pregnancy / statistical model / young adult / Adolescent / Adult / Antioxidants / Biomarkers / Body Mass Index / Chemokine CXCL10 / Cytokines / Diabetes, Gestational / Fatty Acids / Female / Fetal Blood / Fibronectins / Humans / Infant, Newborn / Interleukins / Linear Models / Mothers / Multivariate Analysis / Pregnancy / Young Adult / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteinsLanguage: InglésRepository: 34Subject: angiotensin II / calcium / connective tissue growth factor / contractile protein / protein Grem1 / scleroprotein / somatomedin B / somatomedin B receptor / somatomedin binding protein 1 / somatomedin binding protein 2 / somatomedin binding protein 3 / somatomedin binding protein 4 / somatomedin binding protein 5 / somatomedin binding protein 6 / somatomedin C / somatomedin C receptor / unclassified drug / bradykinin / animal experiment / animal model / animal tissue / Article / calcium homeostasis / controlled study / coronary artery blood flow / Ctgf gene / extracellular matrix / gene / gene expression / Grem1 gene / heart muscle contractility / heart muscle fibrosis / heart weight / histology / Igf1 gene / Igf1r gene / Igf2 gene / Igf2r gene / Igfbp1 gene / Igfbp2 gene / Igfbp3 gene / Igfbp4 gene / Igfbp5 gene / Igfbp6 gene / male / mouse / nonhuman / protein blood level / real time polymerase chain reaction / regulatory mechanism / reperfusion injury / animal / body weight / cardiac muscle / deficiency / drug effects / gene expression regulation / genetics / heart contraction / hemodynamics / metabolism / organ size / pathology / perfusion / transgenic mouse / vasoconstriction / vasodilatation / Angiotensin II / Animals / Body Weight / Bradykinin / Extracellular Matrix / Gene Expression Regulation / Hemodynamics / Insulin-Like Growth Factor I / Mice, Transgenic / Myocardial Contraction / Myocardium / Organ Size / Perfusion / Real-Time Polymerase Chain Reaction / Vasoconstriction / Vasodilation / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Application of microbial electrolysis cells to treat spent yeast from an alcoholic fermentationLanguage: InglésRepository: 34Subject: Antigen-antibody reactions / Electrolysis / Electrolytic cells / Ethanol / Fermentation / Hydrogen / Microbial fuel cells / Regenerative fuel cells / Yeast / Alcoholic fermentation / COD removal / COD removal efficiency / Coulombic efficiency / Electron sink / Ethanol addition / P-values / Treatment conditions / Hydrogen production / alcohol / hydrogen / organic matter / biotechnology / brewing industry / chemical oxygen demand / concentration (composition) / efficiency measurement / electrokinesis / ethanol / fermentation / microbial activity / yeast / acclimatization / alcoholic fermentation / Article / autolysis / controlled study / current density / electrolysis / electron / fermentation optimization / fermentation technique / microbial community / microbial degradation / microbial electrolysis cell / nonhuman / priority journal / reactor / spent yeast / waste component removal / bacterium / biochemical oxygen demand / chemistry / equipment design / metabolism / pH / temperature / Autolysis / Bacteria / Biological Oxygen Demand Analysis / Electrons / Equipment Design / Hydrogen-Ion Concentration / Temperature / Yeasts / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Reproducibility of fluorescent expression from engineered biological constructs in E. coliLanguage: InglésRepository: 34Subject: DNA structure / gene expression regulation / promoter region / reproducibility / biosynthesis / Escherichia coli / genetic transcription / genetics / good laboratory practice / metabolism / protein engineering / transcription initiation / green fluorescent protein / Green Fluorescent Proteins / Laboratory Proficiency Testing / Promoter Regions, Genetic / Protein Engineering / Reproducibility of Results / Transcription, Genetic / Transcriptional Activation / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A novel immune evasion strategy of Candida albicans: Proteolytic cleavage of a salivary antimicrobial peptideLanguage: InglésRepository: 34Subject: aspartic proteinase / histatin 5 / antiinfective agent / saliva protein / article / Candida albicans / cell activity / commensal / enzyme release / fungal cell / Human immunodeficiency virus infection / infection sensitivity / innate immunity / mouth mucosa / nonhuman / protein analysis / protein degradation / thrush / hydrolysis / immunology / metabolism / Anti-Infective Agents / Hydrolysis / Salivary Proteins and Peptides / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Genome-wide binding patterns of thyroid hormone receptor betaLanguage: InglésRepository: 34Subject: thyroid hormone receptor beta / transcription factor AP 1 / transcription factor CTCF / ligand / protein binding / RNA / 3' untranslated region / 5' untranslated region / animal experiment / animal tissue / article / binding kinetics / binding site / controlled study / gene cluster / gene control / gene expression / gene repression / gene sequence / gene targeting / genetic association / genetic transcription / genetic transfection / human / human cell / liver cell / mouse / nonhuman / nucleotide sequence / protein analysis / protein function / protein localization / sequence analysis / animal / C57BL mouse / cell line / chemistry / DNA microarray / DNA responsive element / DNA sequence / gene expression regulation / genome / HepG2 cell line / liver / metabolism / multigene family / plasmid / Animals / Binding Sites / Cell Line / Gene Expression Regulation / Genome / Hep G2 Cells / Humans / Ligands / Liver / Mice / Mice, Inbred C57BL / Multigene Family / Oligonucleotide Array Sequence Analysis / Plasmids / Protein Binding / Response Elements / Sequence Analysis, DNA / Thyroid Hormone Receptors beta / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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