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Title: Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteinsLanguage: InglésRepository: 34Subject: angiotensin II / calcium / connective tissue growth factor / contractile protein / protein Grem1 / scleroprotein / somatomedin B / somatomedin B receptor / somatomedin binding protein 1 / somatomedin binding protein 2 / somatomedin binding protein 3 / somatomedin binding protein 4 / somatomedin binding protein 5 / somatomedin binding protein 6 / somatomedin C / somatomedin C receptor / unclassified drug / bradykinin / animal experiment / animal model / animal tissue / Article / calcium homeostasis / controlled study / coronary artery blood flow / Ctgf gene / extracellular matrix / gene / gene expression / Grem1 gene / heart muscle contractility / heart muscle fibrosis / heart weight / histology / Igf1 gene / Igf1r gene / Igf2 gene / Igf2r gene / Igfbp1 gene / Igfbp2 gene / Igfbp3 gene / Igfbp4 gene / Igfbp5 gene / Igfbp6 gene / male / mouse / nonhuman / protein blood level / real time polymerase chain reaction / regulatory mechanism / reperfusion injury / animal / body weight / cardiac muscle / deficiency / drug effects / gene expression regulation / genetics / heart contraction / hemodynamics / metabolism / organ size / pathology / perfusion / transgenic mouse / vasoconstriction / vasodilatation / Angiotensin II / Animals / Body Weight / Bradykinin / Extracellular Matrix / Gene Expression Regulation / Hemodynamics / Insulin-Like Growth Factor I / Mice, Transgenic / Myocardial Contraction / Myocardium / Organ Size / Perfusion / Real-Time Polymerase Chain Reaction / Vasoconstriction / Vasodilation / 7 INGENIERÍA Y TECNOLOGÍA
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Title: From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”Language: InglésRepository: 34Subject: high density lipoprotein cholesterol / high mobility group B1 protein / macrophage migration inhibition factor / macrophage migration inhibition factor 2 / pancreatic ribonuclease / protein kinase B / reactive oxygen metabolite / STAT3 protein / toll like receptor 4 / troponin I / troponin T / tumor necrosis factor / unclassified drug / vascular endothelial cadherin / atherectomy / atherogenesis / atherosclerosis / cardiac muscle cell / cardiovascular magnetic resonance / chronic kidney disease / cohort analysis / comorbidity / coronary artery bypass graft / disease association / disease course / disseminated intravascular clotting / drug eluting stent / Escherichia coli / heart infarction size / heart mitochondrion / heart protection / heart surgery / hemolytic uremic syndrome / human / immunosuppressive treatment / immunothrombosis / in vivo study / innate immunity / insulin dependent diabetes mellitus / multicenter study (topic) / myocardial ischemia reperfusion injury / non ST segment elevation myocardial infarction / nonhuman / oxidative stress / percutaneous coronary intervention / pilot study / protein expression / protein phosphorylation / randomized controlled trial (topic) / retinopathy / Review / sepsis / signal transduction / ST segment elevation myocardial infarction / thrombosis / animal / cardiology / cardiovascular disease / procedures / theranostic nanomedicine / trends / Animals / Cardiology / Cardiovascular Diseases / Humans / Theranostic Nanomedicine / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Cell source determines the immunological impact of biomimetic nanoparticlesLanguage: InglésRepository: 34Subject: Antigen-antibody reactions / Biocompatibility / Biomimetics / Cell membranes / Drug delivery / Drug products / Immunology / Nanoparticles / Biomimetic nanoparticles / Biomimicry / Comprehensive evaluation / Immunobiology / Immunological effects / Nanovector / Systemic administration / Time-lapse microscopy / Biological materials / alanine aminotransferase / aspartate aminotransferase / biomimetic material / creatinine / gamma interferon / interleukin 10 / interleukin 12 / interleukin 1alpha / interleukin 1beta / interleukin 2 / interleukin 3 / interleukin 6 / leukolike vector / multistage nanovector / nanocarrier / nanoparticle / reactive oxygen metabolite / transcription factor RelA / tumor necrosis factor alpha / unclassified drug / biomaterial / nanocapsule / animal cell / animal experiment / animal tissue / Article / biocompatibility / cell interaction / controlled study / cytokine release / drug delivery system / human / human cell / in vitro study / in vivo study / internalization / leukocyte membrane / liver function / macrophage / mononuclear phagocyte / mouse / nonhuman / opsonization / phagocytosis / priority journal / protein expression / static electricity / surface charge / time lapse imaging / zeta potential / animal / Bagg albino mouse / cell culture / comparative study / drug effects / evaluation study / immunology / innate immunity / leukocyte / Animals / Biocompatible Materials / Biomimetic Materials / Cells, Cultured / Immunity, Innate / Leukocytes / Mice / Mice, Inbred BALB C / Nanocapsules / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Genome-wide binding patterns of thyroid hormone receptor betaLanguage: InglésRepository: 34Subject: thyroid hormone receptor beta / transcription factor AP 1 / transcription factor CTCF / ligand / protein binding / RNA / 3' untranslated region / 5' untranslated region / animal experiment / animal tissue / article / binding kinetics / binding site / controlled study / gene cluster / gene control / gene expression / gene repression / gene sequence / gene targeting / genetic association / genetic transcription / genetic transfection / human / human cell / liver cell / mouse / nonhuman / nucleotide sequence / protein analysis / protein function / protein localization / sequence analysis / animal / C57BL mouse / cell line / chemistry / DNA microarray / DNA responsive element / DNA sequence / gene expression regulation / genome / HepG2 cell line / liver / metabolism / multigene family / plasmid / Animals / Binding Sites / Cell Line / Gene Expression Regulation / Genome / Hep G2 Cells / Humans / Ligands / Liver / Mice / Mice, Inbred C57BL / Multigene Family / Oligonucleotide Array Sequence Analysis / Plasmids / Protein Binding / Response Elements / Sequence Analysis, DNA / Thyroid Hormone Receptors beta / 7 INGENIERÍA Y TECNOLOGÍA
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Title: A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulenceLanguage: InglésRepository: 34Subject: amino acid / arginine / bacterial protein / histidine / protein Mga / transcriptome / unclassified drug / virulence factor / mry protein, Streptococcus pyogenes / amino acid substitution / animal experiment / animal model / Article / bacterial gene / bacterial genome / bacterial strain / bacterial virulence / bacterium culture / codon / controlled study / gene expression / gene sequence / human / human cell / infectious arthritis / Macaca fascicularis / mga gene / mouse / nonhuman / nuclear magnetic resonance imaging / phenotype / priority journal / regulator gene / single nucleotide polymorphism / skin infection / soft tissue infection / Streptococcus group A / animal / arthropathy / cell line / female / genetics / hairless mouse / metabolism / microbiology / missense mutation / pathogenicity / pathology / Streptococcus infection / Streptococcus pyogenes / Amino Acid Substitution / Animals / Bacterial Proteins / Cell Line / Female / Genome, Bacterial / Humans / Joint Diseases / Mice / Mice, Hairless / Mutation, Missense / Polymorphism, Single Nucleotide / Streptococcal Infections / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cellsLanguage: InglésRepository: 34Subject: barium / beta naphtoylbrevetoxin / brevenal / brevetoxin / calcium ion / ciguatoxin / ciguatoxin 1B / natural product / nicotine / SNARE protein / sodium ion / tetrodotoxin / unclassified drug / voltage gated sodium channel / antidote / calcium / catecholamine / drug derivative / sodium / sodium channel / thiobutabarbital / thiopental / animal cell / article / catecholamine release / chromaffin cell / ciguatera / controlled study / drug mechanism / exocytosis / neurosecretion / neurotoxicity / nonhuman / sodium cell level / sodium transport / animal / cattle / drug effect / metabolism / secretion / Bovinae / Ciguatera / Dinophyceae / Animals / Antidotes / Calcium / Catecholamines / Cattle / Chromaffin Cells / Ciguatera Poisoning / Ciguatoxins / Neurosecretion / Sodium / Sodium Channels / Thiopental / 7 INGENIERÍA Y TECNOLOGÍA
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Title: The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob miceLanguage: InglésRepository: 34Subject: eprotirome / hormone receptor stimulating agent / liothyronine / sobetirome / thyroid hormone receptor / thyroid hormone receptor agonist / triacylglycerol / unclassified drug / 3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid / acetic acid derivative / anilide / glucose 6 phosphatase / glucose blood level / phenol derivative / animal experiment / animal model / animal tissue / Article / body temperature / controlled study / glucose tolerance / glycemic control / insulin resistance / insulin sensitivity / liver level / male / mouse / nonalcoholic fatty liver / nonhuman / ob/ob mouse / agonists / animal / biosynthesis / dose response / drug effects / enzyme induction / metabolism / mouse mutant / Non-alcoholic Fatty Liver Disease / time factor / Mus / Acetates / Anilides / Animals / Blood Glucose / Body Temperature / Dose-Response Relationship, Drug / Enzyme Induction / Glucose-6-Phosphatase / Insulin Resistance / Male / Mice / Mice, Obese / Phenols / Receptors, Thyroid Hormone / Time Factors / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathwayLanguage: InglésRepository: 34Subject: mammalian target of rapamycin / nanoparticle / paclitaxel / phosphatidylinositol 3 kinase / protein kinase B / rapamycin / target of rapamycin kinase / animal experiment / animal model / animal tissue / antineoplastic activity / breast cancer / cancer inhibition / conference paper / controlled study / drug delivery system / drug potentiation / drug tumor level / female / in vitro study / liver / mouse / nanoencapsulation / nanopharmaceutics / nonhuman / particle size / protein phosphorylation / protein targeting / spleen / animal / apoptosis / cell proliferation / drug effects / human / Mammary Neoplasms, Animal / MCF 7 cell line / metabolism / nude mouse / signal transduction / tumor cell line / Animalia / Mus / Animals / Apoptosis / Cell Line, Tumor / Cell Proliferation / Female / Humans / MCF-7 Cells / Mice / Mice, Nude / Paclitaxel / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Signal Transduction / Sirolimus / TOR Serine-Threonine Kinases / 7 INGENIERÍA Y TECNOLOGÍA
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Title: Changes in T-tubules and sarcoplasmic reticulum in ventricular myocytes in early cardiac hypertrophy in a pressure overload rat modelLanguage: InglésRepository: 34Subject: calcium ion / aniline derivative / calcium / Fluo 4 / fluorescent dye / ion / xanthene derivative / animal cell / animal experiment / animal model / animal tissue / aorta constriction / Article / beta adrenergic stimulation / bone mass / calcium signaling / cell count / cell structure / cell volume / controlled study / decay time constant / density / diffusion / ex vivo study / heart left ventricle overload / heart muscle cell / heart muscle contractility / heart performance / heart ventricle hypertrophy / heart weight / male / nonhuman / priority journal / rat / sarcolemma / sarcoplasmic reticulum / tissue distribution / transverse tubular system / animal / cardiac muscle cell / cardiomegaly / cell culture / chemistry / confocal microscopy / cytology / disease model / fluorescence recovery after photobleaching / metabolism / microtubule / pathology / pressure / Wistar rat / Aniline Compounds / Animals / Calcium / Calcium Signaling / Cardiomegaly / Cells, Cultured / Disease Models, Animal / Fluorescence Recovery After Photobleaching / Fluorescent Dyes / Ions / Male / Microscopy, Confocal / Microtubules / Myocytes, Cardiac / Pressure / Rats / Rats, Wistar / Sarcoplasmic Reticulum / Xanthenes / 7 INGENIERÍA Y TECNOLOGÍA
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